Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CD8<sup>+</sup> cytolytic T cell clones derived against the <i>Plasmodium yoelii</i> circumsporozoite protein protect against malaria

1 Jan 1991

Abstract excerpt

Immunization of BALB/c mice with radiation-attenuated Plasmodium yoelii sporozoites induces cytotoxic T lymphocytes (CTL) specific for an epitope located within the amino acid sequence 277-288 of the P. yoelii circumsporozoite (CS) protein. Several CD8+ CTL clones were derived from the spleen cells of sporozoite-immunized mice, all displaying an apparently identical epitope specificity. All the clones induced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Malaria Research and Control
Share to Mosquito-borne diseases and control
Share to Vector-borne infectious diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1716146
DOI: 10.1093/intimm/3.6.579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CD8<sup>+</sup> cytolytic T cell clones derived against the <i>Plasmodium yoelii</i> circumsporozoite protein protect against malariaPMID 1716146Read ↗

A T-cell response to a liver-stage <i>Plasmodium</i> antigen is not boosted by repeated sporozoite immunizationsSemantic proximity Read ↗

Protracted Sterile Protection with<i>Plasmodium yoelii</i>Pre‐erythrocytic Genetically Attenuated Parasite Malaria Vaccines Is Independent of Significant Liver‐Stage Persistence and Is Mediated by CD8<sup>+</sup>T CellsSemantic proximity Read ↗

Conserved Protective Mechanisms in Radiation and Genetically Attenuated uis3(-) and uis4(-) Plasmodium SporozoitesSemantic proximity Read ↗

Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccinationSemantic proximity Read ↗

Class II-Restricted Protective Immunity Induced by Malaria SporozoitesSemantic proximity Read ↗

HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles.Semantic proximity Read ↗

Chemovaccination with a novel antimalarial targeting the late liver stage induces durable immunity against malariaSemantic proximity Read ↗

A strong CD8+ T cell response is elicited using the synthetic polypeptide from the C-terminus of the circumsporozoite protein of Plasmodium berghei together with the adjuvant QS-21: quantitative and phenotypic comparison with the vaccine model of irradiated sporozoites.Semantic proximity Read ↗

Development of a Novel CD4 <sup>+</sup> TCR Transgenic Line that Reveals a Dominant Role for CD8 <sup>+</sup> DC and CD40-Signaling in the Generation of Helper and CTL Responses to Blood Stage MalariaSemantic proximity Read ↗

Importance of the Immunodominant CD8 + T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced ProtectionSemantic proximity Read ↗

A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletionSemantic proximity Read ↗

Germinal center activity and B cell maturation promote protective antibody responses against <i>Plasmodium</i> pre-erythrocytic infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.