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Article

Class II-Restricted Protective Immunity Induced by Malaria Sporozoites

27 Dec 2007

Abstract excerpt

The irradiated-sporozoite vaccine elicits sterile immunity against Plasmodium parasites in experimental rodent hosts and human volunteers. Based on rodent malaria models, it has been proposed that CD8+ T cells are the key protective effector mechanism required in sporozoite-induced immunity. To investigate the role of class II-restricted immunity in protective immunity, we immunized beta2-microglobulin knockout...

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PMID: 18160479
DOI: 10.1128/iai.00566-07

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