Article
Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome.
Circulation. Genomic and precision medicine - 1 Feb 2022
Gray Belinda, Baruteau Alban-Elouen, Antolin Albert A, Pittman Alan, Sarganas Giselle, Molokhia Mariam, Blom Marieke T, Bastiaenen Rachel, Bardai Abdenasser, Priori Silvia G, Napolitano Carlo, Weeke Peter E, Shakir Saad A, Haverkamp Wilhelm, Mestres Jordi, Winkel Bo Gregers, Witney Adam A, Chis-Ster Irina, Sangaralingam Ajanthah, Camm A John, Tfelt-Hansen Jacob, Roden Dan M, Tan Hanno L, Garbe Edeltraut, Sturkenboom Miriam, Behr Elijah R
Abstract excerpt
BACKGROUND: Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk. METHODS: Among 153 aLQTS patients (mean age 58 years [range, 14-88], 98.7% White, 85.6% symptomatic), computational methods identified proteins interacting most significantly with 216 QT-prolonging drugs. All cases underwent sequencing of 31 candidate genes arising from this...
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