Article
Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals.
International journal of epidemiology - 1 Apr 2013
Khan Tauseef A, Shah Tina, Prieto David, Zhang Weili, Price Jackie, Fowkes Gerald R, Cooper Jackie, Talmud Philippa J, Humphries Steve E, Sundstrom Johan, Hubacek Jaroslav A, Ebrahim Shah, Lawlor Debbie A, Ben-Shlomo Yoav, Abdollahi Mohammad R, Slooter Arjen J C, Szolnoki Zoltan, Sandhu Manjinder, Wareham Nicholas, Frikke-Schmidt Ruth, Tybjærg-Hansen Anne, Fillenbaum Gerda, Heijmans Bastiaan T, Katsuya Tomohiro, Gromadzka Grazyna, Singleton Andrew, Ferrucci Luigi, Hardy John, Worrall Bradford, Rich Stephen S, Matarin Mar, Whittaker John, Gaunt Tom R, Whincup Peter, Morris Richard, Deanfield John, Donald Ann, Davey Smith George, Kivimaki Mika, Kumari Meena, Smeeth Liam, Khaw Kay-Tee, Nalls Michael, Meschia James, Sun Kai, Hui Rutai, Day Ian, Hingorani Aroon D, Casas Juan P
Abstract excerpt
BACKGROUND: At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the...
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