Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains.

The European journal of neuroscience - 1 Dec 2006

McLin Jessica Pilar, Thompson Leslie Michels, Steward Oswald

Abstract excerpt

In mice, the genetic background determines susceptibility to hippocampal neurodegeneration induced by the excitotoxin kainic acid (KA). If genetic background plays as significant a role in the striatum, the area most affected in Huntington's disease (HD), it is important to characterize intrinsic differences in neuronal susceptibility in mouse strains used in HD models. This study was performed to investigate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kainic Acid

Share to Mice, Inbred CBA

Share to Mice, Inbred DBA

Share to Mice, Inbred ICR

Share to Nerve Degeneration

Share to Neurotoxins

Source

Identifiers

PMID: 17156374
DOI: 10.1111/j.1460-9568.2006.05198.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains.PMID 17156374Read ↗

Susceptibility to excitotoxic and metabolic striatal neurodegeneration in the mouse is genotype dependent.Semantic proximity Read ↗

Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.Semantic proximity Read ↗

Modulation of cell death by mouse genotype: differential vulnerability to excitatory amino acid-induced lesions.Semantic proximity Read ↗

Genetic basis of kainate-induced excitotoxicity in mice: phenotypic modulation of seizure-induced cell death.Semantic proximity Read ↗

Genetic control of sensitivity to hippocampal cell death induced by kainic acid: a quantitative trait loci analysis.Semantic proximity Read ↗

Behavioural analysis and susceptibility to CNS injury of four inbred strains of mice.Semantic proximity Read ↗

Differences in ionotropic glutamate receptor subunit expression are not responsible for strain-dependent susceptibility to excitotoxin-induced injury.Semantic proximity Read ↗

Systems analysis of genetic variation in MPTP neurotoxicity in mice.Semantic proximity Read ↗

Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.Semantic proximity Read ↗

Strain and colony differences in the neurotoxic sequelae of MK-801 visualized with the amino-cupric-silver method.Semantic proximity Read ↗

Increased susceptibility of glutathione peroxidase-1 transgenic mice to kainic acid-related seizure activity and hippocampal neuronal cell death.Semantic proximity Read ↗

MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.