Article
Strain and colony differences in the neurotoxic sequelae of MK-801 visualized with the amino-cupric-silver method.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Nov 2003
Bueno Adrian, de Olmos Soledad, Manzini Fernando, Desmond Nancy L, de Olmos Jose
Abstract excerpt
The strain and sex of a species under investigation may influence the animal's physiological response to a variety of stimuli. Strain and sex differences are important considerations when evaluating animal models. In the rodent MK-801 model of schizophrenia, degenerative changes occur widely in the main olfactory system and in a number of cortical brain regions. In the present report, we compare the effects of...
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