Article
Mvb12 is a novel member of ESCRT-I involved in cargo selection by the multivesicular body pathway.
Molecular biology of the cell - 1 Feb 2007
Oestreich Andrea J, Davies Brian A, Payne Johanna A, Katzmann David J
Abstract excerpt
The multivesicular body (MVB) sorting pathway impacts a variety of cellular functions in eukaryotic cells. Perhaps the best understood role for the MVB pathway is the degradation of transmembrane proteins within the lysosome. Regulation of cargo selection by this pathway is critically important for normal cell physiology, and recent advances in our understanding of this process have highlighted the endosomal...
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