Article
Diabetic nephropathy: of mice and men.
Advances in chronic kidney disease - 1 Apr 2005
Breyer Matthew D, Böttinger Erwin, Brosius Frank C, Coffman Thomas M, Fogo Agnes, Harris Raymond C, Heilig Charles W, Sharma Kumar
Abstract excerpt
Accumulating evidence supports intrinsic genetic susceptibility as an important variable in the progression of diabetic nephropathy in people. Mice provide an experimental platform of unparalleled power for dissecting the genetics of mammalian diseases; however, phenotypic analysis of diabetic mice lags behind that already established for humans. Standardized benchmarks of hyperglycemia, albuminuria, and...
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