Article
Development of novel PRODAN-labeled nucleosides as base-discriminating fluorescent probes.
Nucleic acids symposium series (2004) - 1 Jan 2006
Tainaka Kazuki, Ikeda Shuji, Tanaka Kazuo, Nishiza Ken-ichiro, Fujiwara Yoshimasa, Okamoto Akimitsu, Saito Isao
Abstract excerpt
We have developed a PRODAN-labeled uridine ((PDN)U), which contains a polarity-sensitive chromophore at the C-5 position of uracil. This paper describes the synthesis and fluorescent properties of oligodeoxy-nucleotides (ODNs) containing PRODAN-labeled nucleosides ((PDN)C, (PDN)A, and (PDN)G). PRODAN chromophore was attached to cytosine at the C-5 position and to purine bases at the C-8 position to extend into...
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