Article
Properties of ferrocene-polyamide compounds as redox active DNA binding molecules toward the SNPs detection.
Nucleic acids symposium series (2004) - 1 Jan 2004
Mizuta Masahiro, Terada Takeshi, Seio Kohji, Sekine Mitsuo
Abstract excerpt
Ferrocene-polyamides having not only sequence discrimination ability but also a redox mediator were synthesized. The affinity and selectivity of these compounds for a DNA duplex having a cognate GCG sequence were investigated by CD spectroscopy. Furthermore, the binding of the ferrocene-polyamides to DNA duplexes immobilized to a gold electrode was detected by cyclic voltammetry (CV) experiments. The...
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