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A single nucleotide polymorphism electrochemical sensor based on DNA-functionalized Cd-MOFs-74 as cascade signal amplification probes.

Mikrochimica acta - 21 Jul 2021

Liu Jia Li, Ma Yu Chan, Yang Tong, Hu Rong, Yang Yun Hui

Abstract excerpt

An ultrasensitive electrochemical sensor has been constructed for the detection of single nucleotide polymorphisms (SNPs) based on DNA-functionalized Cd-MOFs-74 as cascade signal amplification probe under enzyme-free conditions. Interestingly, the introduction of an auxiliary probe did not disturb the detection of SNP targets, but could bind more Cd-MOFs-74 signal elements to enhance the different pulse...

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PMID: 34291388
DOI: 10.1007/s00604-021-04924-9

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