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Article

The cataract-causing mutation G98R in human alphaA-crystallin leads to folding defects and loss of chaperone activity.

Molecular vision - 15 Nov 2006

Singh Devendra, Raman Bakthisaran, Ramakrishna Tangirala, Rao Ch Mohan

Abstract excerpt

PURPOSE: The objective of this study is to understand the molecular basis of cataract that develops due to the mutation of the glycine-98 residue to arginine in alphaA-crystallin. METHODS: The glycine-98 residue was mutated to arginine by site-directed mutagenesis. The expression, structural and chaperone properties and thermal stability of the mutant, G98RalphaA-crystallin have been studied. The secondary and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17149363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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