Article
Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract.
FEBS letters - 15 Dec 2011
Validandi Vakdevi, Reddy V Sudhakar, Srinivas P N B S, Mueller Niklaus H, Bhagyalaxmi S G, Padma T, Petrash J Mark, Reddy G Bhanuprakash
Abstract excerpt
Previously we identified a novel mutation (F71L) in the αA-crystallin gene associated with early onset of age-related cataract. However, it is not known how the missense substitution translates into reduced chaperone-like activity (CLA), and how the structural and functional changes lead to early onset of the disease. Herein, we show that under native conditions the F71L-mutant is not significantly different from...
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