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The Double-Edged Sword of αB-Crystallin Chaperone Activity: Insights from P39L Mutant at N-terminal region

2023-08-21

Abstract excerpt

The substitution of leucine to proline at position 39 (P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study aimed to investigate the effects of the P39L mutation on the structural and functional features of human αB-Cry. The mutant protein was expressed in Escherichia coli ( E. coli ) and purified using anion exchang...

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Literature Corpus work
ddd4275e-b976-5dbb-bc5f-e3952fffadcd
DOI
10.21203/rs.3.rs-3258838/v1
Open publication

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The Double-Edged Sword of αB-Crystallin Chaperone Activity: Insights from P39L Mutant at N-terminal regionDOI 10.21203/rs.3.rs-3258838/v1
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