Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional analysis of SNP rs76740365 G>A in exon-3 of the alpha A-crystallin gene in lens epithelial cells.

Molecular vision - 1 Jan 2022

Zhao Zhennan, Sun Yang, Fan Qi, Jiang Yongxiang, Lu Yi

Abstract excerpt

Purpose: To clarify the effect of a previously identified single nucleotide polymorphism (SNP; rs76740365 G>A) in the exon-3 of the alpha A-crystallin (CRYAA) gene on the properties of CRYAA and to investigate its function in human lens epithelial cells (HLECs). Methods: The human recombinant wild-type and mutant CRYAA (E156K) were constructed, and the molecular weight was measured by mass spectrometry. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crystallins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Molecular Chaperones

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36338667
PMCID: PMC9603911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional analysis of SNP rs76740365 G>A in exon-3 of the alpha A-crystallin gene in lens epithelial cells.PMID 36338667Read ↗

Structural and functional analysis of SNP rs76740365 G>A in exon-3 of alpha A-crystallin gene in lens epithelial cellsSemantic proximity Read ↗

A novel silent mutation E83E of αA-crystallin in age-related cataract with impaired chaperone functionSemantic proximity Read ↗

[Comparison on molecular characteristics of human gamma D-crystallin protein and its five mutations].Semantic proximity Read ↗

A novel mutation (F71L) in alphaA-crystallin with defective chaperone-like function associated with age-related cataract.Semantic proximity Read ↗

The Double-Edged Sword of αB-Crystallin Chaperone Activity: Insights from P39L Mutant at N-terminal regionSemantic proximity Read ↗

Differential role of arginine mutations on the structure and functions of α-crystallin.Semantic proximity Read ↗

S209W mutation enhance π-π interactions in the fourth Greek-key of βA3/A1-crystallin linking with aggregation formation and stress susceptibility.Semantic proximity Read ↗

Cataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity.Semantic proximity Read ↗

The cataract-causing mutation G98R in human alphaA-crystallin leads to folding defects and loss of chaperone activity.Semantic proximity Read ↗

Structural and functional characterization of D109H and R69C mutant versions of human αB-crystallin: The biochemical pathomechanism underlying cataract and myopathy development.Semantic proximity Read ↗

Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human αB-crystallin.Semantic proximity Read ↗

Characterization of a mutant R11H αB-crystallin associated with human inherited cataract.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.