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Article

Smoking and colorectal cancer in Lynch syndrome: results from the Colon Cancer Family Registry and the University of Texas M.D. Anderson Cancer Center.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2010

Pande Mala, Lynch Patrick M, Hopper John L, Jenkins Mark A, Gallinger Steve, Haile Robert W, LeMarchand Loic, Lindor Noralane M, Campbell Peter T, Newcomb Polly A, Potter John D, Baron John A, Frazier Marsha L, Amos Christopher I

Abstract excerpt

PURPOSE: Lynch syndrome family members with inherited germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), and cases typically have tumors that exhibit a high level of microsatellite instability (MSI). There is some evidence that smoking is a risk fac...

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Identifiers

PMID: 20145170
DOI: 10.1158/1078-0432.CCR-09-1877
PMCID: PMC2822883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20145170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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