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Article

COX-2-Dependent and COX-2-Independent Mode of Action of Celecoxib in Human Liver Cancer Cells

16 Mar 2011

Abstract excerpt

Celecoxib (Celebrex((R)), Pfizer) is a selective cyclooxygenase-2 (COX-2) inhibitor with chemopreventive and antitumor effects. However, it is now well known that celecoxib has several COX-2-independent activities. To better understand COX-2-independent molecular mechanisms underlying the antitumor activity of celecoxib, we investigated the expression profile of the celecoxib-treated COX-2-positive (Huh7) and...

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PMID: 21410330
DOI: 10.1089/omi.2010.0092

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