Article
Angiotensin II type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II.
European journal of clinical pharmacology - 1 Jan 2007
Lim Hyeong-Seok, Cho Joo-Youn, Oh Dal-Seok, Chung Jae-Yong, Hong Kyoung-Sup, Bae Kyun-Seop, Yu Kyung-Sang, Lee Kyung-Hoon, Jang In-Jin, Shin Sang-Goo
Abstract excerpt
BACKGROUND: The angiotensin II type 1 receptor (AT1R) 1166A/C polymorphism is reported to be implicated in cardiovascular diseases. The association between the 1166A/C polymorphism and diastolic blood pressure (DBP) changes in response to exogenous angiotensin II and valsartan was evaluated by pharmacokinetic and pharmacodynamic modeling. METHODS: Thirteen normotensive, healthy adults (six with the 1166A/A...
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