Article
Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2000
Spiering W, Kroon A A, Fuss-Lejeune M M, Daemen M J, de Leeuw P W
Abstract excerpt
Several investigations have shown heterogeneity in the functional responses to angiotensin II (Ang II) in patients with essential hypertension. The present study was initiated to evaluate whether the A(1166)C polymorphism of the Ang II type 1 receptor (AT(1)R) gene contributes to this variability in Ang II responses. After 7 days of a high-sodium diet (220 mmol Na(+) per day), we measured in 42 essential...
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