Article
Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension.
Journal of hypertension - 1 Apr 2010
Hannila-Handelberg Tuula, Kontula Kimmo K, Paukku Kirsi, Lehtonen Jukka Y, Virtamo Jarmo, Tikkanen Ilkka, Hiltunen Timo P
Abstract excerpt
OBJECTIVE: In order to get insight into possible genetic determinants of antihypertensive drug action, we analysed the relations between polymorphisms of the genes of the renin-angiotensin-aldosterone system and acute effects of ACE inhibition on blood pressure as well as circulating renin and aldosterone levels in hypertensive patients. METHODS: A total of 315 hypertensive patients referred for problems in drug...
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