Article
Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells.
Cancer research - 1 Dec 2006
Lyons Gretchen E, Moore Tamson, Brasic Natasha, Li Mingli, Roszkowski Jeffrey J, Nishimura Michael I
Abstract excerpt
The CD8 coreceptor on T cells has two functions. Namely, CD8 acts to stabilize the binding of the T-cell receptor (TCR) to the peptide-MHC complex while localizing p56(lck) (lck) to the TCR/CD3 complex to facilitate early signaling events. Although both functions may be critical for efficient activation of a CTL, little is known about how the structural versus signaling roles of CD8, together with the relative...
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