Article
Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array.
Cancer research - 1 Dec 2006
Wong Kwong-Kwok, Tsang Yvonne T M, Chang Yi-Mieng, Su Jack, Di Francesco Angela M, Meco Daniela, Riccardi Riccardo, Perlaky Laszlo, Dauser Robert C, Adesina Adekunle, Bhattacharjee Meenakshi, Chintagumpala Murali, Lau Ching C
Abstract excerpt
Using single nucleotide polymorphic (SNP) allele arrays, we analyzed 28 pediatric gliomas consisting of 14 high-grade gliomas and 14 low-grade gliomas. Most of the low-grade gliomas had no detectable loss of heterozygosity (LOH) in any of the 11,562 SNP loci; exceptions were two gangliogliomas (3q and 9p), one astrocytoma (6q), and two subependymal giant cell astrocytomas (16p and 21q). On the other hand, all...
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