Article
Genomic changes in gliomas detected using single nucleotide polymorphism array in formalin-fixed, paraffin-embedded tissue: superior results compared with microsatellite analysis.
The Journal of molecular diagnostics : JMD - 1 Sept 2011
Harada Shuko, Henderson Lindsay B, Eshleman James R, Gocke Christopher D, Burger Peter, Griffin Constance A, Batista Denise A S
Abstract excerpt
Deletion or loss of heterozygosity (LOH) in chromosomes 1p and 19q in oligodendrogliomas (ODGs) have diagnostic, prognostic, and therapeutic implications. Current clinical assays are limited because the probes or primers interrogate only limited genomic segments. We investigated the use of single nucleotide polymorphism (SNP) arrays for identifying genomic changes in gliomas from FFPE tissues. DNA was extracted...
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