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Article

ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.

Biochemistry - 12 Dec 2006

Lamarche Brandon J, Kumar Sandeep, Tsai Ming-Daw

Abstract excerpt

We previously demonstrated that the DNA repair system encoded by the African swine fever virus (ASFV) is both extremely error-prone during the single-nucleotide gap-filling step (catalyzed by ASFV DNA polymerase X) and extremely error-tolerant during the nick-sealing step (catalyzed by ASFV DNA ligase). On the basis of these findings we have suggested that at least some of the diversity known to exist among ASFV...

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Identifiers

PMID: 17144676
DOI: 10.1021/bi0613325
PMCID: PMC2584803

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