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Article

Slow PPi release enhances fidelity of the SARS-CoV-2 RNA dependent RNA polymerase.

The Journal of biological chemistry - 1 Jun 2026

Dangerfield Tyler L, Marko Ingrid, Johnson Kenneth A

Abstract excerpt

Viral RNA-dependent RNA polymerases (RdRps) must balance replication speed with fidelity, preserving genome integrity while permitting enough variability for viral adaptation. The SARS-CoV-2 RdRp complex (non-structural protein 12/7/8) achieves this through the interplay of its intrinsic replication fidelity and a potential proofreading exonuclease complex (NSP10/14). Here, we comprehensively quantify the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41999896
DOI: 10.1016/j.jbc.2026.111457
PMCID: PMC13208697

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