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Article

Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study.

The Journal of rheumatology - 1 Feb 2007

Snelgrove Tara, Lim Sooyeol, Greenwood Celia, Peddle Lynette, Hamilton Sean, Inman Robert, Rahman Proton

Abstract excerpt

OBJECTIVE: Functional single nucleotide polymorphisms within the ectoplasmic domain of the Toll-like receptor 4 (TLR4) gene have been shown to result in an endotoxin-hyporesponsive phenotype and aberrant signal transduction for bacterial agonists. TLR4 is in proximity to a genome-wide linkage peak in 9q32-33. Given the proposed function and location of TLR4, we examined the association of 2 functional variants of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Share to Spondylitis, Ankylosing

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Source

Identifiers

PMID: 17143969

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study.PMID 17143969Read ↗

Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population.Semantic proximity Read ↗

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.Semantic proximity Read ↗

TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis.Semantic proximity Read ↗

Clinical characteristics and frequency of TLR4 polymorphisms in Brazilian patients with ankylosing spondylitis.Semantic proximity Read ↗

Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population.Semantic proximity Read ↗

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.Semantic proximity Read ↗

No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population.Semantic proximity Read ↗

Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events.Semantic proximity Read ↗

Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: a meta-analysis.Semantic proximity Read ↗

Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.Semantic proximity Read ↗

Toll-like receptor 4 gene polymorphisms in polymyalgia rheumatica and elderly-onset rheumatoid arthritis.Semantic proximity Read ↗

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