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Article

TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis.

Annals of the rheumatic diseases - 1 Aug 2006

Adam R, Sturrock R D, Gracie J A

Abstract excerpt

BACKGROUND: Immunoregulatory genes and Gram negative gut bacteria are thought to be important in disease expression in ankylosing spondylitis (AS). OBJECTIVE: To compare the frequency of two common and functional TLR4 mutations (Asp299Gly, and Thr399Ile) between patients with AS and HLA-B27 healthy controls. METHODS: The TLR4 genotypes of patients and healthy HLA-B27 controls were determined using allele-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16837493
DOI: 10.1136/ard.2005.045476
PMCID: PMC1798236

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis.PMID 16837493Read ↗

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Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population.Semantic proximity Read ↗

No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study.Semantic proximity Read ↗

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.Semantic proximity Read ↗

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