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Article

Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population.

Rheumatology (Oxford, England) - 1 Oct 2006

Gergely P, Blazsek A, Weiszhár Z, Pazár B, Poór G

Abstract excerpt

OBJECTIVES: Bacteria have long been suggested as aetiological factors in the genetically susceptible host in spondylarthropathies, including ankylosing spondylitis (AS) and reactive arthritis (ReA). Variability of the Toll-like receptor 4 (TLR4) gene has been shown to play a role in the inflammat...

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Source

Identifiers

PMID: 16567359
DOI: 10.1093/rheumatology/kel062

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16567359-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Lack of genetic association of the Toll-like receptor 4 (TLR4) Asp299Gly and Thr399Ile polymorphisms with spondylarthropathies in a Hungarian population.PMID 16567359Read ↗

TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis.Semantic proximity Read ↗

No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis.Semantic proximity Read ↗

Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population.Semantic proximity Read ↗

Clinical characteristics and frequency of TLR4 polymorphisms in Brazilian patients with ankylosing spondylitis.Semantic proximity Read ↗

Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: a meta-analysis.Semantic proximity Read ↗

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population.Semantic proximity Read ↗

A functional polymorphism of TIR-domain-containing adaptor protein is not associated with axial spondyloarthritis.Semantic proximity Read ↗

Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study.Semantic proximity Read ↗

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.Semantic proximity Read ↗

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.Semantic proximity Read ↗

A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis.Semantic proximity Read ↗

Genetic Polymorphisms of Toll-like receptors 2 and 9 as Susceptibility Factors for the Development of Ankylosing Spondylitis and Psoriatic Arthritis.Semantic proximity Read ↗

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