Article
No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis.
Annals of the rheumatic diseases - 1 Feb 2005
van der Paardt M, Crusius J B A, de Koning M H M T, Morré S A, van de Stadt R J, Dijkmans B A C, Peña A S, van der Horst-Bruinsma I E
Abstract excerpt
OBJECTIVES: Ankylosing spondylitis (AS) is a multifactorial and polygenic disease. Apart from HLA, other genes very probably play a role in disease susceptibility. Indigenous bacteria of the gastrointestinal flora appear to play a role in the pathogenesis of the disease; therefore, genes controling the innate and acquired immune response are good candidates to study disease susceptibility. CD14 and Toll-like...
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