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Article

Establishment of a novel model of chondrogenesis using murine embryonic stem cells carrying fibrodysplasia ossificans progressiva-associated mutant ALK2.

Biochemical and biophysical research communications - 12 Dec 2014

Fujimoto Mai, Ohte Satoshi, Shin Masashi, Yoneyama Katsumi, Osawa Kenji, Miyamoto Arei, Tsukamoto Sho, Mizuta Takato, Kokabu Shoichiro, Machiya Aiko, Okuda Akihiko, Suda Naoto, Katagiri Takenobu

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder characterized by heterotopic endochondral ossification in soft tissue. A mutation in the bone morphogenetic protein (BMP) receptor ALK2, R206H, has been identified in patients with typical FOP. In the present study, we established murine embryonic stem (ES) cells that express wild-type human ALK2 or typical mutant human ALK2 [ALK2(R206H)] under the...

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PMID: 25446088
DOI: 10.1016/j.bbrc.2014.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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