Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.

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Article

Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein.

The Journal of biological chemistry - 8 Apr 1994

Gack S, Vallon R, Schaper J, Rüther U, Angel P

Abstract excerpt

Using specific cDNAs isolated from mouse fibroblasts we determined tissue-specific expression of different matrix metalloproteinase genes: both stromelysin-1 and collagenase IV are highly expressed in heart and lung, whereas collagenase I is expressed most abundantly in skeletal muscle, kidney, and bone. High basal level expression of stromelysin-2 is found in heart and kidney. Like in man and rat, the...

Topics

3T3 Cells
Animals
Base Sequence
Bone Neoplasms
Carcinogens
Cell Line, Transformed
Cloning, Molecular
Collagenases
Cyclic AMP
DNA, Complementary
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 10

Matrix Metalloproteinase 3

Matrix Metalloproteinase 9

Metalloendopeptidases

Mice

Mice, Transgenic

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8144618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8144618-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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