Article
Triplet repeat instability correlates with dinucleotide instability in primary breast cancer.
Oncology reports - 1 Jan 2007
Pizzi Claudia, Di Maio Massimo, Daniele Santa, Mastranzo Paolo, Spagnoletti Ilaria, Limite Gennaro, Pettinato Guido, Monticelli Antonella, Cocozza Sergio, Contegiacomo Alma
Abstract excerpt
The expansion of triplet repeat microsatellite sequences is the molecular correlate of anticipation in a number of rare Mendelian neurodegenerative disorders. This finding prompted us to study these sequences in primary breast cancer in which there is evidence of genetic anticipation. We used a PCR/silver stain method to determine whether triplet-repeat instability (TRI) was present in DNA from malignant breast...
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