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Article

Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability.

Cancer letters - 20 Sept 1999

Minobe K, Bando K, Fukino K, Soma S, Kasumi F, Sakamoto G, Furukawa K, Higuchi K, Onda M, Nakamura Y, Emi M

Abstract excerpt

The extent to which microsatellite instability (MI) contributes to the etiology of breast cancer has not been established in any large-scale studies. We examined 528 samples of tumor DNA from patients with primary breast cancer for MI, using 14 polymorphic CA-repeat markers. The frequency of MI in these tumors was unexpectedly low (10/528, 1.9%). The ten MI+ tumors were analyzed for mutations in five potential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10503872
DOI: 10.1016/s0304-3835(99)00181-0

Genes

PTEN
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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