Article
Instability at dinucleotide and trinucleotide repeats in breast cancer.
International journal of oncology - 1 Oct 2000
Ottini L, Palli D, Falchetti M, D'Amico C, Noviello C, Saieva C, Russo A, Corsi A M, Masala G, Paglierani M, Vezzosi V, Bianchi S, Mariani-Costantini R
Abstract excerpt
We analyzed 7 mono-, 6 di- and 2 trinucleotide repeat loci in a well characterized series of 69 breast cancer cases, treated in the period 1985-1986 and followed for 12 years. Tumor-associated allele contractions or expansions were observed only at di- and trinucleotide repeats, and were detected in 14/69 cases (20%), of which 7 (10%) showed instability at 2 or more loci (10%). No alterations were detected at...
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