Article
An unstable triplet repeat in a gene related to myotonic muscular dystrophy.
Science (New York, N.Y.) - 6 Mar 1992
Fu Y H, Pizzuti A, Fenwick R G, King J, Rajnarayan S, Dunne P W, Dubel J, Nasser G A, Ashizawa T, de Jong P
Abstract excerpt
Synthetic oligonucleotides containing GC-rich triplet sequences were used in a scanning strategy to identify unstable genetic sequences at the myotonic dystrophy (DM) locus. A highly polymorphic GCT repeat was identified and found to be unstable, with an increased number of repeats occurring in D...
Topics
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Human, Pair 19
- Cloning, Molecular
- DNA
- Humans
- Molecular Sequence Data
- Mutation
- Myotonic Dystrophy
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid