Article
Unstable triplet repeat sequences: a source of cancer mutations?
Stem cells (Dayton, Ohio) - 1 Mar 1995
Panzer S, Kuhl D P, Caskey C T
Abstract excerpt
Numerous mutations have been related to various types of cancer. Short tandem repeats (STRs) are repetitive DNA elements that are often polymorphic in normal populations. Triplet repeat expansion has been related pathogenetically to six diseases: fragile X syndrome, fragile X E syndrome, spinobulbar muscular atrophy, myotonic dystrophy, Huntington's disease, and spinocerebellar ataxia type 1. The characteristics...
Topics
- Base Sequence
- DNA
- Fragile X Syndrome
- Genome, Human
- Humans
- Huntington Disease
- Muscular Atrophy
- Mutation
- Myotonic Dystrophy
- Neoplasms
- Repetitive Sequences, Nucleic Acid
- Spinocerebellar Degenerations