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Article

Variations of Epstein-Barr virus nuclear antigen 1 in Epstein-Barr virus-associated gastric carcinomas from Guangzhou, southern China.

PloS one - 1 Jan 2012

Chen Jian-ning, Zhang Na-na, Jiang Ye, Hui Da-yang, Wen Zi-jin, Li Hai-gang, Ding Yun-gang, Du Hong, Shao Chun-kui

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is the only viral protein consistently expressed in all EBV-associated malignancies, and play a critical role in the onset, progression, and/or maintenance of these tumors. Based on the signature changes at amino acid residue 487, EBNA1 is classified into five distinct subtypes: P-ala, P-thr, V-leu, V-val and V-pro. In the present study, the sequence variations...

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Identifiers

PMID: 23189182
DOI: 10.1371/journal.pone.0050084
PMCID: PMC3506544

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