Article
-391 C to G substitution in the regulator of G-protein signalling-2 promoter increases susceptibility to the metabolic syndrome in white European men: consistency between molecular and epidemiological studies.
Journal of hypertension - 1 Jan 2007
Freson Kathleen, Stolarz Katarzyna, Aerts Raymond, Brand Eva, Brand-Herrmann Stefan-Martin, Kawecka-Jaszcz Kalina, Kuznetsova Tatiana, Tikhonoff Valérie, Thijs Lutgarde, Vermylen Jos, Staessen Jan A, Van Geet Chris
Abstract excerpt
BACKGROUND: The regulator of G-protein signalling-2 (RGS2) is a key factor in adipogenesis. We hypothesized that the metabolic syndrome, of which obesity is an important component, might be related to genetic variation in RGS2. METHODS AND RESULTS: We screened the human RGS2 gene. We tested the functionality of a common genetic variant in vitro, ex vivo, and in epidemiological study involving six European...
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