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C3435T polymorphism of the MDR1 gene is not associated with blood levels of hypothalamus-pituitary-adrenal axis hormones in healthy male subjects.

Genetics and molecular research : GMR - 8 Mar 2017

Suzuki A, Matsumoto Y, Shirata T, Goto K, Enokido M, Otani K

Abstract excerpt

In vitro studies have shown that multidrug resistance protein 1 (MDR1) has an affinity for cortisol; however, in vivo association studies on the relationship between MDR1 gene polymorphisms and blood cortisol levels have produced inconsistent results. Therefore, we examined the effects of the C3435T polymorphism of the MDR1 gene on blood levels of hypothalamus-pituitary-adrenal (HPA) axis hormones such as...

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PMID: 28290618
DOI: 10.4238/gmr16019447

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