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Article

Functional polymorphism of the human multidrug resistance gene (MDR1) and polydipsia-hyponatremia in schizophrenia.

Neuromolecular medicine - 1 Jan 2008

Shinkai Takahiro, De Luca Vincenzo, Utsunomiya Kensuke, Sakata Shinichi, Inoue Yoshiaki, Fukunaka Yuko, Hwang Rudi, Ohmori Osamu, Kennedy James L, Nakamura Jun

Abstract excerpt

P-glycoprotein (P-gp), which is coded by the MDR1 gene, in the brain capillary endothelial cell limits the entry of many drugs including antipsychotics into the brain. The aim of this study is to examine whether a functional polymorphism, a C to T substitution at position 3435 in exon 26 of the MDR1 gene, is associated with susceptibility to polydipsia-hyponatremia in schizophrenia (SCZ) in a Japanese...

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PMID: 18543120
DOI: 10.1007/s12017-008-8041-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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