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Article

Viral Interference with B7-1 Costimulation: A New Role for Murine Cytomegalovirus Fc Receptor-1

1 Dec 2006

Abstract excerpt

Murine CMV (MCMV), a beta-herpesvirus, infects dendritic cells (DC) and impairs their function. The underlying events are poorly described. In this study, we identify MCMV m138 as the viral gene responsible for promoting the rapid disappearance of the costimulatory molecule B7-1 (CD80) from the cell surface of DC. This was unexpected, as m138 was previously identified as fcr-1, a putative virus-encoded FcR. m138...

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PMID: 17142739
DOI: 10.4049/jimmunol.177.12.8422

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