The CMV-encoded G protein-coupled receptors M33 and US28 play pleiotropic roles in immune evasion and alter host T cell responses

Abstract excerpt

Introduction Human cytomegalovirus (HCMV) is a global health threat due to its ubiquity and lifelong persistence in infected people. During latency, host CD8+ T cell responses to HCMV continue to increase in a phenomenon known as memory inflation. We used murine CMV (MCMV) as a model for HCMV to characterize the memory inflation response to wild-type MCMV (KP) and a latency-defective mutant (ΔM33stop), which...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19 Impact on Reproduction
• Share to Cytomegalovirus and herpesvirus research
• Share to Herpesvirus Infections and Treatments