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Article

Selenoprotein expression is essential in endothelial cell development and cardiac muscle function.

Neuromuscular disorders : NMD - 1 Feb 2007

Shrimali Rajeev K, Weaver James A, Miller Georgina F, Starost Matthew F, Carlson Bradley A, Novoselov Sergey V, Kumaraswamy Easwari, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

LoxP-Cre technology was used to remove the selenocysteine tRNA gene, trsp, in either endothelial cells or myocytes of skeletal and heart muscle to elucidate the role of selenoproteins in cardiovascular disease. Loss of selenoprotein expression in endothelial cells was embryonic lethal. A 14.5-day-old embryo had numerous abnormalities including necrosis of the central nervous system, subcutaneous hemorrhage and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17142041
DOI: 10.1016/j.nmd.2006.10.006
PMCID: PMC1894657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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