Article
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England) - 1 Nov 2011
Rasmussen Tara L, Kweon Junghun, Diekmann Mackenzie A, Belema-Bedada Fikru, Song Qingfeng, Bowlin Kathy, Shi Xiaozhong, Ferdous Anwarul, Li Tongbin, Kyba Michael, Metzger Joseph M, Koyano-Nakagawa Naoko, Garry Daniel J
Abstract excerpt
Er71 mutant embryos are nonviable and lack hematopoietic and endothelial lineages. To further define the functional role for ER71 in cell lineage decisions, we generated genetically modified mouse models. We engineered an Er71-EYFP transgenic mouse model by fusing the 3.9 kb Er71 promoter to the EYFP reporter gene. Using FACS and transcriptional profiling, we examined the EYFP(+) population of cells in Er71...
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