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Article

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.

The Biochemical journal - 15 Feb 2009

Carlson Bradley A, Schweizer Ulrich, Perella Christine, Shrimali Rajeev K, Feigenbaum Lionel, Shen Liya, Speransky Svetlana, Floss Thomas, Jeong Soon-Jeong, Watts Jennifer, Hoffmann Victoria, Combs Gerald F, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

STAF [Sec (selenocysteine) tRNA gene transcription activating factor] is a transcription activating factor for a number of RNA Pol III- and RNA Pol II-dependent genes including the Trsp [Sec tRNA gene], which in turn controls the expression of all selenoproteins. Here, the role of STAF in regulat...

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Identifiers

PMID: 18973473
DOI: 10.1042/BJ20081304
PMCID: PMC2752860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18973473-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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