Article
The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.
The Biochemical journal - 15 Feb 2009
Carlson Bradley A, Schweizer Ulrich, Perella Christine, Shrimali Rajeev K, Feigenbaum Lionel, Shen Liya, Speransky Svetlana, Floss Thomas, Jeong Soon-Jeong, Watts Jennifer, Hoffmann Victoria, Combs Gerald F, Gladyshev Vadim N, Hatfield Dolph L
Abstract excerpt
STAF [Sec (selenocysteine) tRNA gene transcription activating factor] is a transcription activating factor for a number of RNA Pol III- and RNA Pol II-dependent genes including the Trsp [Sec tRNA gene], which in turn controls the expression of all selenoproteins. Here, the role of STAF in regulating expression of Sec tRNA and selenoproteins was examined. We generated transgenic mice expressing the Trsp transgene...
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