Article
Abnormal cardiac energetics in patients carrying the A3243G mtDNA mutation measured in vivo using phosphorus MR spectroscopy.
Biochimica et biophysica acta - 9 Jul 2004
Lodi Raffaele, Rajagopalan Bheeshma, Blamire Andrew M, Crilley Jenifer G, Styles Peter, Chinnery Patrick F
Abstract excerpt
Cardiomyopathy is a frequent cause of morbidity and mortality in patients carrying the A3243G transition in the mitochondrial DNA (mtDNA) tRNALeu(UUR) gene, the most common heteroplasmic single mtDNA defect. We used phosphorus magnetic resonance spectroscopy (31P-MRS) to look for evidence of an in vivo bioenergetics defect in patients carrying the A3243G mtDNA mutation with and without echocardiographic signs of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.