Article
Prolongation of serum half-life of interleukin 2 and augmentation of lymphokine-activated killer cell activity by pepstatin in mice.
Cancer research - 15 Feb 1990
Ohnishi H, Lin K M, Chu T M
Abstract excerpt
We reported previously using a murine model that the kidney is the organ involved in catabolism of exogenous human recombinant interleukin 2 (IL-2) and that cathepsin D, a major renal acid protease, is responsible for the degradation of IL-2. In the present report also using BALB/c mice we have investigated the effect of in vivo pepstatin, an acid protease inhibitor, treatment on serum half-life of IL-2, and...
Topics
- Animals
- Cathepsin D
- Female
- Half-Life
- Interleukin-2
- Kidney
- Killer Cells, Lymphokine-Activated
- Mice
- Mice, Inbred BALB C
- Oligopeptides
- Pepstatins
- Phenotype