Article
A sex-specific role of type VII adenylyl cyclase in depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Nov 2006
Hines Lisa M, Hoffman Paula L, Bhave Sanjiv, Saba Laura, Kaiser Alan, Snell Larry, Goncharov Igor, LeGault Lucie, Dongier Maurice, Grant Bridget, Pronko Sergey, Martinez Larry, Yoshimura Masami, Tabakoff Boris
Abstract excerpt
Major depression represents a complex mental disorder. The identification of biological markers that define subtypes of major depressive disorder would greatly facilitate appropriate medical treatments, as well as provide insight into etiology. Reduced activity of the cAMP signaling system has been implicated in the etiology of major depression. Previous work has shown low adenylyl cyclase activity in platelets...
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