Article

Elevated <i>P2×7r</i> and <i>P2×4r</i> transcripts levels in the Flinders Sensitive Line Rats, a genetic animal model of depression

2018-08-18

Abstract excerpt

P2×7 and P2×4 receptors (P2×7R and P2×4R, respectively) are ligand-gated ion channels activated by adenosine triphosphate (ATP), which have been associated to dysfunctional processes in stress responses linked to depression, such as neurotransmitter release, cognition, sleep, energy, appetite, immune and endocrine dysfunction. Clinical studies indicate that polymorphisms in the P2×7r gene results in increased sus...

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Literature Corpus work: 8ef45574-b23d-5df9-8f7e-a99086d7f106
DOI: 10.1101/395194

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