Article
Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region.
Molecular medicine (Cambridge, Mass.) - 29 May 2025
Ren Shimin, Wang Xian, Huang Xueying, Chen Liyang, Zhang Bing, Li Yang, Huang Xin
Abstract excerpt
BACKGROUND: The prevalence of depression in women is approximately twice that in men. Differences in androgens levels between men and women, due to gonadal differences, may be associated with the development of depression, although the underlying mechanisms are not well understood. METHODS: We evaluated the depressive phenotypes of female mice following low-dose androgen treatment using a variety of behavioral...
Read the complete abstract on PubMedTopics
- Animals
- Female
- Hippocampus
- Mice
- Depression
- Androgens
- Dehydroepiandrosterone